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Introduction: Coronavirus disease (COVID-19) has been declared a global pandemic. In this unprecedented situation, the intimate relationship, sexual behavior, and family functions of partners have also undergone unique changes. There are few reports on whether sexual behavior and family function affect intimate relationships between partners, especially among people aged 18 to 44 years.

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Aim: To analyze the influence of sociodemographic characteristics, family function, and changes in sexual behavior on male-female intimacy, the independent contributions of the aforementioned factors in this population group are required to be further investigated.

Methods: In the present study, 284 Chinese citizens aged 18-44 years completed the online questionnaire. The univariate analysis and cluster multiple linear regression were used to analyze the associations between sociodemographic factors, sexual-behavior changes, family function, and male-female intimacy.

Main outcome measure: Family adaptation, partnership, growth, affection, resolve (APGAR) Scale and Relationship Assessment Scale were used to evaluate participants' family function and their intimacy. Details of the participants (sociodemographic and sexual factors) were obtained.

Results: The summary scores, with Relationship Assessment Scale and APGAR scales, were 27.19 4.49 and 6.76 2.28, respectively. About 43.3% of participants reported a decrease in sexual frequency. There were considerable differences among age, education level, sexual desire, sexual satisfaction, quality of sexual life, family function with male-female intimacy (P

Conclusions: Sexual behavior factors and family function were important independent determinants of partner intimacy among people aged 18-44 years. It can provide supportive information for health care to develop intervention plans and services to promote the harmonious development of intimate relationship. Feng Y-J, Fan Y-J, Su Z-Z, et al. Correlation of Sexual Behavior Change, Family Function, and Male-Female Intimacy Among Adults Aged 18-44 Years During COVID-19 Epidemic. Sex Med 2021;9:100301.

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To perform NIPT, cfDNA is extracted from maternal plasma and sequenced using short reads and high-throughput DNA sequencing. Sequenced reads are aligned to the reference human genome using a short read aligner. Aneuploidy is called if the number of reads mapped to each chromosome differs from its expectation based on a comparison with a set of baseline samples. The general approach is usually referred to as a read depth strategy.

(a) Workflow of NIPT; (b) The z-scores across all the autosomes for a T21 sample, the triangles highlight chromosomes 13, 18 and 21 for which we test for aneuploidy; (c) Visual display of the criteria used to call fetal sex and chromosome aneuploidy

Raw read counts from high-throughput sequencing technologies typically do not follow theoretical counting statistics. The excess variance, introduced in part by the polymerase chain reaction steps, is correlated with the GC content of the DNA sequence. Various methods have been proposed to correct for these biases. RAPIDR implements two methods from the literature: the normalized chromosome value (NCV) method (Sehnert et al., 2011) and weighting of counts by GC content bin (Fan and Quake, 2010). These methods require a reference sample set, in contrast to the open source tool described by Straver et al. (2014). NCV computes the ratio between the counts mapped to the chromosome of interest and another chromosome. The chromosome used in the denominator is chosen to minimize the variance of the NCV ratios. In the GC bin weighting method (Fan and Quake, 2010), we first determine the read count in each bin, and then compute the average count as a function of GC content (using discrete intervals of 0.5% for GC proportion). Counts in each bin are then weighted by Wi=M/Mi, where M is the average counts across all bins and Mi is the average count in bin i. We also implemented a third method for GC correction based on principal component analysis (PCA), which as far we know, has not been used in the context of NIPT. In the PCA method, we first use the euploid samples in the baseline set to find the principal components by treating the count ratios in each bin as a variable. Then, we regress the count ratios in each bin with the first 10 principal components, with the assumption that they represent systematic noise. We find that PCA provides higher sensitivity than GC bin weighting correction in exchange for lower specificity (Supplementary Table S1).

An important issue is technical sample-to-sample variability. If a sample is technically too distinct, it will not be appropriate to include it in the baseline. We propose quality control checks to ensure that such technical issues are not affecting the calls. One useful check is to make sure that the z-score for all autosomes (aside from the chromosomes for which we suspect aneuploidy) fall between the expected range. RAPIDR provides functions to report and visualize this easily, and Figure 1b shows the quality control output from one sample.

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Chinese actress Fan Bingbing, who has returned after months of hiding due to tax evasion controversies, is reportedly getting married next February and retiring from the entertainment industry after that.

According to a Hong Kong media outlet, Fan Bingbing will be getting married to her fiance, Li Chen, on February 2, 2019. Moreover, the outlet has reported that Fan Bingbing will be leaving the world of entertainment after getting married.

Actress Fan Bingbing and actor Li Chen, who began openly dating in 2015 and later announced their engagement, are a well-known couple in China. Fan Bingbing, in particular, is known as one of the top 5 highest paid actresses in the world.

After months of living outside the public eye and numerous rumors claiming that she was imprisoned, kidnapped or dead, she was finally slapped with a $130 million USD fine, which she paid off in just 2 days.

After 123 days of living in seclusion, Fan Bingbing finally shared a post on her SNS account, apologizing for her mistakes. She also expressed shame for her actions and thanks to the Communist Party and fans.

Although reports of her marriage and her retirement have not yet been confirmed, after so many rumors and scandals, it would not be surprising that the actress wants out of the industry. Meanwhile, netizens have been speculating as to why the actress is retiring so suddenly:

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